Methodist Girls’ High School, Mamfe follows the curriculum laid out by the Ghana Education Service (GES), designed to meet national and international standards. The Senior High School (SHS) curriculum, based on the Common Core Programme (CCP), emphasizes academic excellence and the development of 21st-century skills. This includes critical thinking, communication, creativity, and collaboration, as well as moral and character development. Core subjects such as English, Mathematics, Science, and Social Studies are complemented by electives in various disciplines like Business, Sciences, and the Arts.

Additionally, the school integrates STEM education into its curriculum, aligning with the government’s recent educational reforms. The curriculum is learner-centred and incorporates hands-on learning, especially through STEM and robotics programs, providing students with a holistic education that prepares them for both higher education and the workforce. This approach ensures that students graduate with a broad skill set necessary for success in an increasingly technology-driven world.